Down-regulated expression of transient receptor potential ankyrin 1 in lichen simplex chronicus
نویسندگان
چکیده
منابع مشابه
Lichen simplex chronicus with a cutaneous horn.
A 55-year-old male developed itching on the anterior aspects of both legs and the right ankle. Gradually over the next 5 years there was thickening of the skin on these areas followed by the appearance of hyperpigmented, scaly, severely itchy plaques. He also noticed the appearance of a thick, hard horn-like structure projecting from the surface of the right ankle lesion for the last 2 years. A...
متن کاملPrurigo nodularis and lichen simplex chronicus.
Emotional tensions in predisposed subjects may play a key role in inducing a pruritic sensation, leading to a scratching that, becoming a self-perpetuating pathomechanism, may represent the main feature of two distinct cutaneous clinical entities: prurigo nodularis and lichen simplex chronicus. Psychogenic factors play a relevant role in both conditions, and they are often associated with depre...
متن کاملModulation of transient receptor vanilloid 1 activity by transient receptor potential ankyrin 1.
Transient receptor potential vanilloid 1 (TRPV1) is a nonselective ligand-gated cation channel responding to noxious heat, protons, and chemicals such as capsaicin. TRPV1 is expressed in sensory neurons and plays a critical role in pain associated with tissue injury, inflammation, and nerve lesions. Transient receptor potential ankyrin 1 (TRPA1) is coexpressed with TRPV1. It is activated by com...
متن کاملLichen Simplex Chronicus That Accompanies Anogenital Warts during the Childhood
Anogenital warts and lichen simplex chronicus (LSC) are rarely seen during the childhood. A 9-year-old girl has been presented to hospital by her parents with itching in the anogenital area. There were anogenital warts and a different erythematous lesion in the perianal region. On the pulpa of the right thumb, there was a wart extending under the nail. The lesions are surgically removed. The re...
متن کاملUrate Crystal Induced Inflammation and Joint Pain Are Reduced in Transient Receptor Potential Ankyrin 1 Deficient Mice – Potential Role for Transient Receptor Potential Ankyrin 1 in Gout
INTRODUCTION In gout, monosodium urate (MSU) crystals deposit intra-articularly and cause painful arthritis. In the present study we tested the hypothesis that Transient Receptor Poten-tial Ankyrin 1 (TRPA1), an ion channel mediating nociceptive signals and neurogenic in-flammation, is involved in MSU crystal-induced responses in gout by utilizing three experi-mental murine models. METHODS Th...
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ژورنال
عنوان ژورنال: Annals of Palliative Medicine
سال: 2020
ISSN: 2224-5820,2224-5839
DOI: 10.21037/apm-20-1712